Abstract: Patients with sever posterior uveitis and/or retinal vasculitis, and unresponsive to oral cytatoxic drugs and/or high doses steroids, were selected for this study. Pulse cyclophosphamide (PCP) was performed by perfusion of 1 g cyclophosphalnide per square meter of body surface in 500 ml of normal saline. PCP was repeated every month after a new evaluation of the patient. 30 mg of prednisolone/day was also given. Actually 102 patients are receiving ...
Abstract: In a separate report we demonstrated that B5 cluster antigens acts as a leading factor for ocular injuries. The question is why in some patients, these antigens does not produce the same lesions. This may be due to a genetic factor(s) which determine resistance to ocular lesions. Two HLA antigens attracted our attention as possible factors. One from the class I (CW4), and the other from the class II (DQW1). DQW1 ...
Abstract: Behcet's Disease (BD) has been found to be related to the first class HLA antigens, the B5. In Iran, B5 is present in 64% of BD patients versus 34% in normal population. The relative risk is 3.33. Uveitis has been demonstrated to be related to the presence of B5. in our study the posterior uveitis was present in 59% of patients with B5 versus 48% without it (p
Abstract: The association of B5 and uveitis has been previously demonstrated. 37 patients with ocular form were studied for HLA, ABC and DR antigens, with a large panel of antisera (A.O.H.W.C panel sera). Results are: Antigen Control Patient Relative R. ...
Abstract: 40 cas de maladie de Behcet ont ete etudies entre 1977 et 1985. Il s'agissait 1 hommes (62 %) et de 129 femmes (38 %). La moyenne d'age est de 25.5 ecart type de 9.1. 334 cas avaient des Iesions muqueuses (98 %). L'aphtose de etait presente dans 333 cas (97 %), I'aphtose genitale dans 245 cas (72%). ~f~es-avatent des lesions cutanees (74 %). Les pseudo-folliculites etaient !ntes dans 257 ...
Abstract: The skin hyper reactivity (SHR) as detected by the pathergy test is a common feature of Behcet's Disease (BD) in Middle East Countries and in Japan, but not in Western Countries. Yazici et al showed it's sensitivity and it's specificity. As the SHR in pathergy test is revealed by a pseudo folliculitis, it may have the same significance as the spontaneous pseudo folliculitis (PF) of BD. Thus if a patient ...
Abstract: In 225 patients with definit Behcet's Disease I5 clinical and 5 paraclinical parameters (CBC,ESR, urinalysis,B5,Pathergy test) were statistically analyzed. The chi-square test (X2) was used for the analysis of difference and P values smaller than 0.05 were accepted as a significative difference between male and female patients. Ophthalmologic manifestations were more frequent in males (80%) than females (63%),X2=7.91,0.01> P> 0.001.The difference concern specially the uveitis (73% males,55% females,X2=7.65,0.01>P>0.001). In osteoarticular ...
Abstract: The sensitivity of the 1971 preliminary criteria for the classification of systemic lupus erythematosus (SLE) was 90% according to Cohen et al (1), who assembled those criteria. This high degree of sensitivity was not found by other investigators (2-6). The1982 revised criteria proposed by Tan et al (7) showed a 96% sensitivity among their patients. In a recent work, Levin et al (8) compared the 1971 and the 1982 American Rheumatism ...
Abstract: In this case study 100 patients with confirmed Behcet's disease have been in reviewed. The following manifestations were observed: buccal aphthous ulcerations 98 per cent, genital ulcerations 63 per cent, positive Behcetine test in 81 per cent, ocular involvement 80 per cent, positive HLA-B5 74 per cent, skin lesions 68 per cent, articular manifestations 63 per cent, digestive problems 21 per cent, thrombophlabitis of the extremities 17 per cent, neurologic ...
Abstract: From 1975 to 1982, 156 patients with systemic lupus erythematosus were seen. 90 % were women, 69 % were aged between 10 to 30 years. 63 % had a deterioration of their general condition. Skin disorders was found in 92 % with 78 % of facial erythema, 46 % photosensitivity, 56 % Alopecia, 9 % Raynauds phenomenon and 19 % oral lesions. Osteoarticular changes were detected in 84 % renal ...